Hot Selling Total Beta-Human Chorionic Gonadotropin Hcg Rapid Testing Kit
Total Beta-Human Chorionic Gonadotropin (β-HCG) Serum Kit (Immunofluorescence) is mainly for the in vitro quantitative determination of β-HCG in human serum for the early detection of pregnancy.
Human Chorionic Gonadotropin (hCG) is a glycoprotein hormone normally produced by placenta during pregnancy. Structurally intact hCG molecules consist of two non-covalently linked polypeptide subunits, the alpha and beta chain subunits. The α-subunit is common to luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid stimulating hormone (TSH), while the β-subunit is unique to hCG. Amino acid residues specific for the β-subunit of hCG confer the immunochemical specificity.
HCG is synthesized by trophoblastic tissue of the placenta in pregnancy, although it can be produced by other cells in various disease states. Serum concentrations of biologically active hCG (nonnicked hCG) rise exponentially in the first trimester of pregnancy, doubling every 48h, to a at about 10 weeks of gestation (weeks since last menstrual period). Concentrations decrease from the 10th to the 16th week of gestation, reaching approximately one-fifth of concentrations, and remain around this concentration until term. The hormone is present in pregnancy serum and urine samples, along with a variety of dissociated or degraded hCG.
With the availability of sensitive quantitative assays for the measurement of serum β-HCG, it has been shown that β-HCG levels can be useful in prediction of spontaneous abortions, aiding in the detection of ectopic pregnancy and multiple gestation.
The assay is a double-antibody sandwich immunoassay for quantitative determination of total β-HCG concentration based on immunofluorescence technology. Add the sample to the sample well of the cartridge. Through chromatography, the sample reacts with the fluorescent latex particles coated with β-HCGmonoclonal antibody Ⅰ on the conjugate pad. The complex spreads ahead along the nitrocellulose membrane captured by β-HCGmonoclonal antibody Ⅱ on the test line. The more β-HCGthe sample contains, the more complexes the test line accumulates. The intensity of fluorescent antibody signal reflects the amount of captured β-HCG. The immunofluorescence quantitative analyzer produced by our company can detect the concentration of β-HCG in the sample.